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Operate by Other folks, together with Dickey, has revealed that upsized mucin secretion while in the airways performs in Considerably the exact same way, involving analogous vesicles (full of mucin in place of neurotransmitters) and synaptotagmin and collaborating proteins.
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Inflammation, frequently elicited by microbial pathogens, shifts mucin sp9 secretion into overdrive. That’s great for trapping and washing away offending microbes, but Should the inflammation persists it may cause difficulties.
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With a special carrier portion included to its sequence, the peptide properly entered the cells. Once the cells had been stimulated to secrete mucin, SP9 lessened secretion by 83%.
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